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Paediatric Research January 2015

The Children’s Research Team at Leighton Hospital has continued to develop the portfolio of Research Studies now available to children and young people within our local population.  We now have a variety of studies actively recruiting which includes areas of care such as Epilepsy, Respiratory, Diabetes and Neonatal care. In doing so, we help to increase the opportunities for patients to take part in clinical research, ensuring that studies are carried out safely and efficiently. This is in line with the Government’s Strategy for UK Life Sciences by improving the environment for commercial and portfolio clinical research in the NHS and in particular the North West Coast area. We are passionate about the contribution that clinical research can make to patient care, and work collaboratively with the North West Coast Network to translate that passion into the effective delivery of studies in our hospital. We make sure that clinical research occupies the place it deserves to in the day-to-day work of our Trust.

Two new studies that are excellent examples of this are the SIFT and the ARCHIE study. SIFT is an important neonatal study looking at the rates of feeding in infants born prematurely and of low birth weight. This study intends to define which rates of feeding are best, faster or slower. Infants recruited to the study are monitored daily whilst the clinical care team continues to provide their routine clinical care. This study will help better define the best rate of feeding, so as to ensure there is continuity in this area in Trusts across the country. ARCHIE will be looking at the early treatment of influenza (flu like illness) with early antibiotics in “at risk” children. This study is essential if we are to identify if by treating this group of patients earlier there is a reduced risk of secondary bacterial infections, re-admission to hospital and quicker recovery time.

If you have any questions about any of the research studies please contact Samantha Tapscott Research Sister on 01270 612123 /07768358891


Ophthalmology Research January 2015

Leighton Hospital’s Ophthalmology Department is actively involved in Research.

The three studies currently open are important in helping us to better understand how to diagnose, treat, cure or prevent age related macular degeneration. In the coming months we will be expanding our portfolio to include areas of dry eye, glaucoma and cataract Research studies.

If you would like to know more about getting involved in any clinical research in this area please contact Research Sister Samantha Tapscott on 01270 612123 or Advanced Nurse Practitioner Lisa Rudy Fitzgerald on bleep 3451 accessed via main switchboard 01270 255141

Emergency Care Research

The Trust's Emergency Care research team continue to recruit patients onto NIHR portfolio studies with a view to improving services for patients in line with evidence-based practice. The research portfolio is expanding at the Trust with new upcoming trials in heart failure, respiratory medicine and gastroenterology. The team continues to work closely in all areas of general medicine and with a large portfolio of trials in Stroke and Rheumatology. The latest results for a recent stroke study ‘CLOTS 3’ looking at Intermittent Pneumatic Compression for VTE prevention for immobile stroke patients made national headlines. MCHFT  took part in this ground-breaking study recruiting 19 patients - BBC News website article (external link, opens in new window)

Oncology Research

The Oncology Research Department continues to go from strength to strength with a portfolio of over 30 studies either actively recruiting or in follow up covering an extensive variety of disease areas.

We are now looking forward to opening our first palliative care study thus expanding the range of trials we can offer to patients at MCHFT.

TVT is a trial comparing the standard three-step approach to analgesia for cancer pain. When first line treatment is ineffective patients commence a weak opioid, if pain control is not achieved a strong opioid is then prescribed. The experimental intervention of a two step approach is the immediate commencement of a strong opioid following first line treatment. The primary objective is to establish whether the two step approach to cancer pain relief can achieve stable pain control more quickly but without increased side-effects compared to the standard three step approach of the WHO analgesic ladder.

If you have any patients who you think might be suitable for any of our Oncology trials, or if you are aware of an NCRN/ NIHR Oncology trial you would be interested in being a Principal Investigator for, please contact one of our team Tel: 01270 273486.


Women's Health Research

Women’s Health Research in the Women’s Health Unit is on-going and involves constantly gathering evidence to improve the future care of women and their babies.  We have a diverse portfolio of trials but two areas we are currently focusing on are improving pregnancy outcomes in women of advanced maternal age and for those who suffer with pre-eclampsia. 

This autumn, a new fetal monitoring trial is set to be launched at the Trust.  Its aim is to determine whether computer analysis with real-time alerts reduces the rate of metabolic acidosis compared to continuous monitoring as previously performed.  This randomised control trial will be offered to women who are identified to need monitoring during labour.   The equipment will be an extra aid for clinicians and will be used alongside their professional judgement.

Follow-up is an essential part to research and we are due to commence a programme of follow-up home visits with women who previously participated in a Healthy Eating and Lifestyle study during their pre and post birth stages.  The study aims to capture the current habits of these ladies 2 years on from the birth of their child. 

If you would like to know more about Reproductive Health Research please contact Caroline Dixon or Janet Brown on 01270 27(3745). 




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